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. 2006 Jan;168(1):310–320. doi: 10.2353/ajpath.2006.050443

Figure 1.

Figure 1

KFS2MT6 survival. A: Map of the KFS2MT transgene. Coding exons of the human K18 gene are shown in black. Hatched rectangles indicate alu sequences. Dotted region indicates the position of the IRES. The sequence of the junction between the IRES and the PyMT coding sequence is shown. Three copies of the SV40 termination sequences are indicated with arrows. The action of Cre recombinase results in the deletion of the termination signals and leaves a single loxP sequence with two translational termination codons. B and C: Kaplan-Meier plots of animals sacrificed because of noticeable alterations in appearance or behavior or found dead. Log-rank test indicated significant differences between all pairs of data. Vertical arrow indicates OHT administrations starting at 42 ± 2 days for 5 consecutive days. B: Bigenic KFS2MT6; MMTV-Cre7 bigenic females and males are compared to monogenic stock. C: Bigenic KFS2MT6; K18CreER animals were treated with OHT. −OHT, untreated animals.