Figure 2.

A comparison of PGHS-2 and iNOS localization in aortic sinus lesions from ApoE^−/−and ApoE^−/−iNOS^−/−mice. Immunohistochemical detection of iNOS and PGHS-2 in aortic sinus lesions from ApoE^−/−(top) and ApoE^−/−iNOS^−/− (bottom) mice fed a Western diet for 4 months. L, lumen; P, plaque; M, media; con, control sections stained with antibody preincubated with antigen. Sections were counterstained with hematoxylin to visualize nuclei. Similar results were observed in aortic sinus lesions from three ApoE^−/− and three ApoE^−/−iNOS^−/− mice.