Figure 3-6704.

Zinc-induced trypsinogen activation in isolated pancreatic acini. a: Zinc (ZnSO₄) was added in vitro at different concentrations (0, 10, 50, 100, 250 μmol/L) for 2 hours. Zinc-induced trypsinogen activation is shown as a percentage of the maximal activated trypsin activity in response to cerulein (10 nmol/L). Values denote means +/− SEM of triplicates, representative of experiments with five animals. b: Influence of Me₂Spm on zinc-induced (2 hours) trypsinogen activation in isolated pancreatic acini. Activation is shown as a percentage of the maximal activated trypsin activity in response to cerulein (10 nmol/L). Means +/− SEM of triplicates of three to nine animals in each group.