Table 2-6704.
Pancreatic SSAT Activities and Polyamine Concentrations in Transgenic Rats after Treatment with Zinc and Me2Spm
| Group | SSAT (pmol/mg/10 minutes) | Putrescine (pmol/mg tissue) | N1-acetyl-spermidine (pmol/mg tissue) | Spermidine (pmol/mg tissue) | Spermine (pmol/mg tissue) | MeSpd (pmol/mg tissue) | Me2Spm (pmol/mg tissue) |
|---|---|---|---|---|---|---|---|
| Control | 29 ± 7 | 3130 ± 1020 | 49 ± 6 | 4140 ± 977 | 437 ± 45 | ND | ND |
| Zn 24 hours | 8600 ± 7020 | 3478 ± 502* | 119 ± 55 | 150 ± 36* | 53 ± 14* | ND | ND |
| Zn 24 hours + Me2Spm | 8820 ± 6660 | 1850 ± 357 | 67 ± 6 | 92 ± 8* | 30 ± 7* | 129 ± 18 | 493 ± 45 |
| Zn 48 hours | 9560 ± 8910 | 1580 ± 256 | 108 ± 53 | 380 ± 76* | 81 ± 25* | ND | ND |
| Zn 48 hours + Me2Spm | 7010 ± 8410 | 2430 ± 850 | 70 ± 10 | 311 ± 84* | 52 ± 19* | 389 ± 112 | 665 ± 180 |
The rats received zinc (10 mg/kg i.p.) without or with Me2Spm (25 mg/kg i.p.) administered 4 and 8 hours after zinc. The animals were sacrificed 24 or 48 hours after zinc. The data are given as means ± SD. There were three to seven rats per group. ND, not detected.
*
P < 0.01 as compared with untreated transgenic control animals.