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. 2006 Jan;168(1):340–348. doi: 10.2353/ajpath.2006.050379

Figure 4.

Figure 4

Expression of HGF/SF and MET in rat carotid arteries after deep (balloon) injury. Expression is demonstrated by green fluorescence for HGF/SF and red fluorescence for MET. HGF/SF immunofluorescence is detected only in lumen-lining cells and in certain areas of the adventitia (A) in uninjured arteries (a) whereas 14 days after injury striking expression of HGF/SF is observed in the newly developed intima and also in SMCs of the underlying media (c). MET immunofluorescence is undetectable in uninjured arteries (b), but very strong in the cells of the neointima 14 days after injury (d). Time course of expression of HGF/SF (e) and MET (f) in rat carotid arteries with no injury or 1, 2, 4, 7, and 14 days after injury. Injury first causes conversion of pro-HGF/SF (αβ) to active, two-chain HGF/SF (α chain is shown) followed by new synthesis of pro-HGF/SF and the subsequent activation. The Western blots are representative of three separate balloon injury experiments.