TABLE 1.
Critical amino acids in high-activity peptides binding to HepG2 cells from P. faciparum CSP, TRAP, STARP, LSA-1, and SALSA
| Protein | Peptide | Sequencea |
|---|---|---|
| CSP | 4383 | NSRSLGENDDGNNEDNEKLR |
| CSP | 4388 | GNGQGHNMPNDPNRNVDENA |
| CSP | 4389 | HNMPNDPNRNVDENANANSA |
| CSP | 4390 | DPNRNVDENANANSAVKNNN |
| TRAP | 5873 | DLFLVNGRDVQNNIVDEIKYREE |
| TRAP | 5877 | KGENPNGFDLDENPENPPNP |
| TRAP | 5885 | SEDRETRPHGRNNENRSYNRKHNNT |
| TRAP | 6481 | YNRKHNNTPKHPEREEHEKPD |
| TRAP | 5897 | REEHEKPDNNKKKAGSDNKY |
| TRAP | 5891 | GAATPYAGEPAPFDETLGEE |
| STARP | 20546 | VIKHNRFLSEYQSNFLGGGY |
| STARP | 20547 | SAALKLVNSKKSGTNVNTKY |
| STARP | 20548 | NSENTNTNNNIPESSSTYTN |
| STARP | 20569 | TSDDELNKDSSDYSEEKENI |
| STARP | 20570 | KSMINAYLDKLDLETVRKIH |
| LSA-1 | 20630 | INGKIIKNSEKDEIIKSNLRY |
| SALSA | 20608 | IWSAEKKDEKEASEQGEESHY |
a
Underlined letters are the critical HepG2 cell binding amino acids from each particular peptide sequence.