TABLE 1.
Gene product | Polymorphism(s) | Postulated effect of polymorphism | Reference(s) |
---|---|---|---|
IL-1β | IL-1B-31C, IL-1B-511T | Increased expression of IL-1β, which induces expression of proinflammatory cytokines and inhibits acid secretion | 63-66, 134, 135 |
IL-1RA | IL-1RN*2 | Reduced expression of IL-1 receptor agonist, which increases IL-1β activity | 135 |
IL-2 | IL-2-330T | Reduced IL-2 expression | 232 |
IL-10 | IL-10 haplotype ATA | Reduced expression of IL-10, which increases proinflammatory cytokine activity | 66 |
TNF | TNF-A-308A | Increased TNF expression, which induces expression of proinflammatory cytokines and inhibits acid secretion | 66, 134 |