TABLE 2.
H. pylori infection of mouse knockout modelsa
| Knockout model (mouse strain[s]) | H. pylori strain | Bacterial density compared to WT | Inflammation compared to control | Reference(s) |
|---|---|---|---|---|
| NOS2−/− (C57BL/6) | SS1 | Similar colonization | More severe gastritis | 32 |
| Gp91phox/NOS2−/− (C57BL/6) | SS1 | Reduced colonization | More severe gastritis | 32 |
| SCID (B- and T-cell deficient) (C57BL/6) | SS1 | Greater colonization | No gastric inflammation | 61 |
| μ-MT (B-cell deficient) (C57BL/6) | SS1 | Reduced colonization | More severe gastritis | 3 |
| MHC class I KO (C57BL/6) | SS1 | Greater colonization | ND | 177 |
| MHC class II KO (C57BL/6) | SS1 | Greater colonization | ND | 177 |
| IFN-γ KO (C57BL/6) | SM326 | ND | No gastric inflammation | 207 |
| IFN-γ KO (C57BL/6) | CPY2052 | Greater colonization | No gastric inflammation | 199,251 |
| IFN-γ KO (C57BL/6 and BALB/c) | SM326 | More frequent recovery of bacteria | ND | 109 |
| IRF-1 KO (C57BL/6) | SS1 | Greater colonization | No gastritis | 212 |
| IL-4 KO (C57BL/6) | SM326 | ND | More severe gastritis | 207 |
| IL-4 KO (C57BL/6 and BALB/c) | SM326 | Similar colonization | ND | 109 |
| IL-4 KO (C57BL/6) | SS1 | Similar colonization | Similar degree of gastritis | 42 |
| IL-4 Tg (IL-4 overexpression) (C3H) | SS1 | Similar colonization | Similar degree of gastritis | 42 |
| IL-10 KO (IL-10+/−, 129 × C57BL/6) | SS1 | Reduced colonization | More severe gastritis | 43 |
| IL-12 KO (C57BL/6) | SS1 | Similar colonization | Similar degree of gastritis | 2 |
| FasL KO (C57BL/6) | SS1 | Similar colonization | Similar degree of gastritis | 107 |
| TNF KO (C57BL/6) | CPY2052 and KP142 | Greater colonization | Similar degree of gastritis | 251 |
| TNF receptor KO (C57BL/6) | Six clinical isolates of H. pylori | ND | Similar degree of gastritis | 229 |
a
This table summarizes the results of selected studies in which transgenic mouse models were infected with Helicobacter pylori. WT, wild type; ND, not determined; KO, knockout.