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. 2006 Jul;26(14):5406–5420. doi: 10.1128/MCB.00161-06

FIG. 2.

FIG. 2.

Location of translocation breakpoints in the CAN1, ALP1, and LYP1 genes. (A) The open reading frame (ORF) of CAN1 is shown. Regions of homology between the CAN1 and LYP1 genes that are longer than 4 bp are boxed with regions of homology that are unique to the CAN1-LYP1 alignment in uppercase letters and regions of homology that are identical in both CAN1-LYP1 and CAN1-ALP1 alignments in lowercase letters. The regions of homology associated with CAN1-LYP1 translocation breakpoints are numbered 1 to 26, with the most 5′ breakpoint having the lowest number; numbered red boxes indicate CAN1-LYP1 breakpoints, and numbered black boxes indicate CAN1-ALP1 breakpoints that occurred within a region of homology that is identical in CAN1-LYP1 and CAN1-ALP1 alignments. (B) The ORF of CAN1 is shown. Stretches of homology between the CAN1 and ALP1 genes that are longer than 4 bp are boxed with regions of homology that are unique to the CAN1-ALP1 alignment in uppercase letters and regions of homology that are identical in both CAN1-LYP1 and CAN1-ALP1 alignments in lowercase letters. Breakpoints are numbered 15 to 28, with the most 5′ breakpoint having the lowest number; numbered blue boxes indicate CAN1-ALP1 breakpoints, and numbered black boxes indicate CAN1-LYP1 breakpoints that occurred within a stretch of homology that is identical in CAN1-LYP1 and CAN1-ALP1 alignments. (C) The ORF of ALP1 is shown. Regions of homology between the ALP1 and LYP1 genes that are longer than 4 bp are boxed. Breakpoints are numbered 29 to 35, with the most 5′ breakpoint having the lowest number; numbered green boxes indicate LYP1-ALP1 breakpoints, and numbered dotted-line boxes indicate ALP1-LYP1 breakpoints that were part of CAN1-LYP1-ALP1-LYP1-ALP1 rearrangements. Breakpoint 34 was observed in LYP1-ALP1 rearrangements as well as in ALP1-LYP1 rearrangements.