TABLE 3.
Expected and observed frequencies of translocation breakpoints in homology blocks of various lengthsa
| Homology length (bp) | Breakpoint frequency for:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
|
CAN1-LYP1
|
LYP1-ALP1
|
CAN1-ALP
|
|||||||
| Expected frequencyb | Observed frequencyc | Ratiod | Expected frequencyb | Observed frequencyc | Ratiod | Expected frequencyb | Observed frequencyc | Ratiod | |
| 1 | 0.146 | 0.064 (3) | 0.4 | 0.150 | 0 | 0 | 0.122 | 0 | 0 |
| 2 | 0.202 | 0.021 (1) | 0.1 | 0.210 | 0 | 0 | 0.211 | 0 | 0 |
| 4 | 0.031 | 0.021 (1) | 0.7 | 0.065 | 0 | 0 | 0.043 | 0 | 0 |
| 5 | 0.141 | 0.213 (10) | 1.5 | 0.061 | 0.064 (3) | 1.0 | 0.110 | 0.333 (6) | 3.0 |
| 6 | 0.026 | 0 | 0 | 0.016 | 0 | 0 | 0.019 | 0.056 (1) | 2.9 |
| 8 | 0.061 | 0.021 (1) | 0.3 | 0.033 | 0 | 0 | 0.078 | 0.278 (5) | 3.6 |
| 9 | 0.010 | 0.106 (5) | 10.2 | 0.009 | 0 | 0 | NA | NA | NA |
| 10 | 0.011 | 0.085 (4) | 7.4 | NA | NA | NA | 0.005 | 0 | 0 |
| 11 | 0.050 | 0.191 (9) | 3.8 | 0.028 | 0 | 0 | 0.005 | 0.111 | 20.2 |
| 12 | 0.007 | 0.021 (1) | 3.1 | NA | NA | NA | NA | NA | NA |
| 13 | 0.007 | 0.021 (1) | 2.9 | NA | NA | NA | NA | NA | NA |
| 14 | 0.023 | 0.191 (9) | 8.2 | NA | NA | NA | 0.014 | 0.056 | 4.0 |
| 16 | NA | NA | NA | 0.008 | 0.021 (1) | 2.7 | 0.008 | 0 | 0 |
| 17 | 0.019 | 0.043 (2) | 2.3 | NA | NA | NA | NA | NA | NA |
| 20 | NA | NA | NA | 0.010 | 0.064 (3) | 6.6 | 0.010 | 0.167 (3) | 17.3 |
| 22 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 29 | NA | NA | NA | 0.014 | 0.170 (8) | 12.2 | NA | NA | NA |
| 41 | NA | NA | NA | 0.019 | 0.596 (28) | 30.6 | NA | NA | NA |
| 47 | NA | NA | NA | 0.022 | 0.116 (4) | 3.8 | NA | NA | NA |
NA (not available) indicates homology blocks of certain lengths that were not found in the specified gene alignment.
The expected frequency of a breakpoint occurring in a homology block of a certain length was calculated by dividing the product of the homology block length and its number of occurrences within the alignment by the total length of the alignment. The total length of the alignment was defined as the sum of the products of homology block length and its number of occurrences.
The observed breakpoint frequency was calculated by dividing the number of observed breakpoints within a homology block of certain length by the total number of breakpoints observed between these two genes. Numbers in parentheses indicate the total number of breakpoints observed in a homology block of this length.
The ratio between the observed and expected number of breakpoints in a homology block of a certain length.