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. 2006 Jul;26(14):5310–5324. doi: 10.1128/MCB.00084-06

FIG. 1.

FIG. 1.

Loss of PSMA in vivo abrogates angiogenesis. Results of in vivo Matrigel plug assay show that (A) hemoglobin (Hg) content is decreased in PSMA-inhibited (n = 6; P = 0.002) or PSMA-null plugs (n = 6; P = 0.0001), (B) microvessel density is decreased in PSMA-null plugs (n = 6; P = 0.014), and (C) hematoxylin and eosin staining of Matrigel plug sections reveals a significant decrease in erythrocyte-containing microvessels in PSMA-null or -inhibited plugs (indicated by arrowheads). WT, wild type; α-PSMA, PSMA-neutralizing antibody; PSMA −/−, PSMA null. *, 0.05 < P > 0.01; **, 0.01 < P > 0.001. Error bars indicate standard deviations.