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Integrin β1 regulates PSMA activity. (A) β1 integrin inhibition (Neutr.) increases PSMA activity (n = 3; P = 0.01), while β1 activation (Act.) decreases PSMA activity (n = 3; P = 0.001). *, 0.05 < P > 0.01; **, 0.01 < P > 0.001. (B) HUVECs incubated on laminin-coated cell culture dishes with a β1-activating antibody (β1-Act. Ab) display protrusions in multiple directions, similar to those of PSMA inhibited cells (PMPA treatment). Error bars indicate standard deviations.
