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. 2006 Aug;26(15):5908–5920. doi: 10.1128/MCB.00269-06

FIG. 1.

FIG. 1.

NADPH oxidase inhibitors block HFS-induced E-LTP. (A) A single 1-second 100-Hz train of HFS (indicated by the arrow) induced E-LTP in vehicle-treated wild-type hippocampal slices (control) but was blocked when HFS was delivered in the presence of either 10 μM DPI or 100 μM apocynin (n = 8 slices; four mice per treatment) (P < 0.0001 by one-way ANOVA) (apocynin versus control, P < 0.001; DPI versus control, P < 0.001; DPI versus apocynin, P > 0.05 by Newman-Keuls multiple comparison test). (B) Two representative fEPSP recordings from time points 1 and 2 in panel A were overlaid to demonstrate potentiation in control slices, which was absent in drug-treated slices. (C) Control slices with or without either 10 μM DPI or 100 μM apocynin applied to slices for 20 min while recording fEPSPs; 10 μM DPI or 100 μM apocynin did not affect baseline fEPSPs (P > 0.05 by one-way ANOVA). (D) Three representative fEPSPs from time points 1, 2, and 3 in panel C were overlaid, demonstrating the lack of change in baseline responses during 1 hour of recording with or without application of either 10 μM DPI or 100 μM apocynin for 20 min.