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Grp78−/− embryos do not hatch from the ZP in vitro. (A) Nested PCR of wild-type (+/+), heterozygous (+/−), and homozygous null (−/−) Grp78 alleles for E3.5 embryos. (B) Morphology of Grp78+/+, Grp78+/−, and Grp78−/− embryos at E3.5 and following 48 and 96 h of culture in vitro. Scale bars indicate 100 μm. The arrowheads indicate the ZP. (C) Summary of the hatching status of E3.5 embryos after 96 h of culture in vitro.
