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. 2006 Aug;26(15):5809–5826. doi: 10.1128/MCB.00024-06

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FIG. 4. — Differential gene expression in Mkl1^−/− mammary glands compared with wild-type mammary tissue. (A) Hierarchical clustering of the 248 probe sets (representing 182 different genes) that are significantly differentially expressed (q value, <0.05) between mammary tissue from Mkl1^−/− and Mkl1^+/+ mice. Mammary glands from either Mkl1^−/− or Mkl1^+/+ dams (three of each) at postpartum day 5 were collected and used for expression profiling analyses. Each column shown in the figure represents one mammary gland tissue sample, and each row represents a probe set. Expression levels are normalized for each probe set, where the mean is zero; expression levels greater than the mean are shown in red, and levels less than the mean are in green. Increasing distance from the mean is represented by increasing color intensity. Two subgroups of the entire 248-probe set involving genes known to be up-regulated during normal mammary gland involution or involved in normal muscle function are shown to the right of the heat map. The DecisionSite for Functional Genomics (version 8.1) module (Spotfire, Inc., Somerville, MA) was used for the hierarchical clustering. Detailed information concerning all 248 probe sets is shown in Table S1 in the supplemental material. KO, knockout; WT, wild type. (B) Known mammary gland involution genes overexpressed in Mkl1^−/− mammary glands from nursing mothers at postpartum day 5.

FIG. 4. — Differential gene expression in Mkl1^−/− mammary glands compared with wild-type mammary tissue. (A) Hierarchical clustering of the 248 probe sets (representing 182 different genes) that are significantly differentially expressed (q value, <0.05) between mammary tissue from Mkl1^−/− and Mkl1^+/+ mice. Mammary glands from either Mkl1^−/− or Mkl1^+/+ dams (three of each) at postpartum day 5 were collected and used for expression profiling analyses. Each column shown in the figure represents one mammary gland tissue sample, and each row represents a probe set. Expression levels are normalized for each probe set, where the mean is zero; expression levels greater than the mean are shown in red, and levels less than the mean are in green. Increasing distance from the mean is represented by increasing color intensity. Two subgroups of the entire 248-probe set involving genes known to be up-regulated during normal mammary gland involution or involved in normal muscle function are shown to the right of the heat map. The DecisionSite for Functional Genomics (version 8.1) module (Spotfire, Inc., Somerville, MA) was used for the hierarchical clustering. Detailed information concerning all 248 probe sets is shown in Table S1 in the supplemental material. KO, knockout; WT, wild type. (B) Known mammary gland involution genes overexpressed in Mkl1^−/− mammary glands from nursing mothers at postpartum day 5.