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. 1999 Mar 16;96(6):3251–3256. doi: 10.1073/pnas.96.6.3251

Figure 3.

Figure 3

CsA and its immunosuppressant and nonimmunosuppressant analogs potentiate cell death induced by SODV148G (black bars) and SODA4V expression (open bars) in PC12 cells (A) and show a protective effect after NGF removal (B). Drugs were added immediately after virus infection and were replenished in fresh media every 3 days. CsA, CsG, and FK506 are immunosuppressive drugs that inhibit calcineurin. PKF 211–811 and PSC833 are nonimmunosuppressants that do not inhibit calcineurin but do inhibit rotamase activity. The cell death induced by FALS-related SODV148G was potentiated by both drug classes (as was SODA4V) but not by CsH and d-lys(dansyl)-8-Cs. Values are expressed as means ± SEM (n = 3).