TABLE 1.
Genotyping results of matings between heterozygotesa
| Age | No. of surviving mice
|
||
|---|---|---|---|
| Homozygote | Heterozygote | Wild type | |
| >3 wk | 0 | 112 | 52 |
| P0 | 22 (0/22) | 62 (61/62) | 28 (28/28) |
| e18.5 | 34 (0/22) | 99 (64/69) | 32 (16/16) |
| e17.5 | 10 | 23 | 11 |
| e16.5 | 14 | 26 | 16 |
| e14.5 | 3 | 4 | 3 |
| e12.5 | 3 | 3 | 2 |
a
The genotyping results of the litters in matings between heterozygotes. No homozygotes were found among animals more than 3 weeks old. To determine the time of death of the pups, timed matings were performed. The numbers in parentheses indicate ratios of pups that were found alive (P0) or survived after resuscitation (e18.5). Although heterozygote mice appear to be overrepresented in e18.5 pups, it is still within a range consistent with Mendelian distribution of a single locus (P > 0.025).