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Normal lymphoid development in Cybr-deficient mice. Lymphocyte populations in thymus or spleen were analyzed by flow cytometry. (A) Thymic CD4 and CD8 single- and double-positive populations (upper panels) as well as double-negative populations DN1 to 4 (as defined by CD25 and CD44 staining) (lower panels) are shown. (B) Spleen CD4 and CD8 T-cell populations (upper panels) and CD19+ B cells (lower panels) were also analyzed. WT, wild type; KO, knockout.
