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Giemsa-stained metaphase spreads of ER-POT1 cells. Cells were grown with tamoxifen (+TAM) (A) or without tamoxifen (−TAM) (B to H) for 24 or 48 h. (A to C) Normal karyotypes. (D) Karyotype of an aneuploid cell with an elevated number of macrochromosomes. (E) Cell with telomere-telomere association (marked with arrowhead). (F) Enlargement of telomere association shown in panel E. (G) Association between long arms of two acrocentric chromosomes. (H) Aggregated/entangled chromosomes.
