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FANCD2 is phosphorylated on S222, T691, and S717 by both ATR and ATM. (A) HeLa cells stably transfected with the cDNA encoding wild-type EGFP-tagged FANCD2 were exposed to siRNA specific for LacZ, ATM, ATR, or both ATM and ATR. After 48 h, whole-cell lysates were prepared and total cellular protein was analyzed by immunoblotting with antisera specific for the indicated proteins. (B) FA-D2 transfectants were subjected to the RDS assay.
