FIG. 3.

Gα_i2^G184S mice are small. (A) Five-week-old homozygous (right) and wt (left) male mice are shown. (B and C) wt (+/+), heterozygote (+/G184S), and homozygote (G184S/G184S) mice were weighed weekly, and means ± standard deviations are shown for male (B) and female (C) animals. Numbers of animals were as follows: +/+, 54 males, 57 females; +/G184S, 74 males, 78 females; G184S/G184S, 18 males, 21 females. Both homozygous and heterozygous mice had significantly reduced body weights compared to age- and sex-matched wt controls (see text for details).