TABLE 2.

Comparison of phenotypes of RGS-insensitive Gα_i2^G184S mice and Gα_i2-deficient mice

Mouse type	Group	Phenotype
RGS-insensitive Gαi2G184S	General	Pre-/neonatal lethality (homozygote Gαi2G184S/G184S and heterozygote Gαi2+/G184S)
		Low body weight
		Short bones
	Hematologic	Large spleen
		Increased monocyte and neutrophil counts
	Cardiac	Daytime tachycardia
		Increased heart organ weight/body weight ratio
		Hyperdynamic function
	Neurobehavioral	Hyperactivity
Gαi2 deficient	Generala	Pre- and postnatal lethality
		Growth retardation apparent at 6 wks of age
	Pathologica	Ulcerative colitis and adenocarcinoma of colon
	Immunologica,b	Increased no. of single positive (mature) T cells with high-intensity CD3 staining in thymus but unaffected lymphocyte homing in spleen
		Impaired marginal zone and B-1 B-cell development
	Hematologicc	Impaired platelet activation
	Cardiacd	Attenuated muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes

^aBased on references 58 and 59.

^bBased on reference 16.

^cBased on reference 35.

^dBased on reference 52.