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The mammalian MBD protein family. The MBDs (green) of each protein share both amino acid and functional homologies. The TRDs (red) share functional homology: they recruit histone deacetylase complexes to silence chromatin. The MBD of MBD2 overlaps the TRD and is indicated by a black line. The RG repeat domain in MBD2 is shown (yellow). The MBD of mammalian MBD3 has amino acid substitutions that do not allow it to recognize methylated DNA. MBD4 is a DNA mismatch repair enzyme (43).
