TABLE 4.

Phenotypic differences found in Psip1 mutant mice in an MF1 background

Phenotype	No.a of mice with a genotype of:
	+/+	+/−	−/−
Infertilityb	Rare	Rare	5/7
Size of testesc (mean % ± SEM)	0.51 (0.01)	0.53 (0.02)	0.34 (0.02)
Epididymal fat padsd	5/5	8/8	0/7
Chronic ulcerative blepharitise	Rare	Rare	20/27
Hind limb extensionf	8/8	11/11	5/13
Normal grip strength	8/8	11/11	5/13
Brachycephalyg	Rare	Rare	23/27
Skeletal transformations
Six attached ribsh	0/5	0/7	2/8
Eight attached ribs	1/5	2/7	0/8
Abnormal C1/C2i	0/2	0/4	2/4
C7 to T1i	0/5	0/7	4/8
T3 to T2j	0/3	0/4	1/4
L6 to S1k	0/2	0/4	3/4

^aUnless otherwise indicated, the data are number of mice that display the observed phenotype/number of mice specifically studied for phenotype. Rare indicates that the number was not determined but the phenotype was rarely observed, if at all, during breeding of >500 offspring.

^bFertility of Psip1^−/− mice was tested by setting up crosses between Psip1^−/− males and at least two WT MF1 females. Mice were considered infertile if no offspring were obtained over a period of approximately 3 months.

^cSize of testes was determined as the weight of both testes expressed as a percentage of body weight.

^dSee Fig. 5A.

^eSee Fig. 5D and E.

^fSee Fig. 5F.

^gSee Fig. 5G and H and 6A.

^hSee Fig. 6C.

ⁱSee Fig. 6D.

^jSee Fig. 6E.

^kSee Fig. 6F.