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. 2000 Mar 14;97(6):2419–2424. doi: 10.1073/pnas.97.6.2419

Table 4.

IC50 values against c-Src for linked binding elements containing catechol analogs

Compound R1 R2 R3 IC50, μM
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[90, 273, n = 2] H OH OH 0.064  ± 0.038
[90, 306, n = 2] H OH H 3.6  ± 0.2
[90, 307, n = 2] H H OH 3.5  ± 0.5
[90, 308, n = 2] H OH OMe 16  ± 12
[90, 309, n = 2] H OMe OH 23  ± 12
[90, 310, n = 2] H OH Cl 4.1  ± 0.2
[90, 311, n = 2] H OH F 4.9  ± 1.1
[90, 312, n = 2] H OH CH2OH 8.5  ± 2.3
[90, 313, n = 2] NO2 OH OH 0.11  ± 0.03

See Table 2 for assay conditions.