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. 2006 Sep 19;1:12. doi: 10.1186/1750-1326-1-12

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Copyright © 2006 Peters et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sepp1(-/-) mice exhibit impaired acquisition of spatial learning and memory. (A) Average escape latency from 4 trials per day. Sepp1(-/-) mice showed a significantly longer latency on days 3 and 6 (n = 10 mice per genotype, Day 3 *p = 0.04, Day 6 *p = 0.04). (B) Linear regression of escape latencies per trial from days 2 to 3 (Sepp1(-/-) slope = 0.5, Sepp1(+/+) slope = -3.5). (C) Time spent searching the 4 quadrants for the hidden platform during a 60 sec probe trial on day 5 (TQ-target quadrant, OP-opposite, R-right, L-left). Both genotypes selectively searched the target quadrant. (D) Day 10 latencies to locate a visible platform in the opposite quadrant from training. Both genotypes demonstrated similar ability to locate the visible platform.