Figure 4.

Dynamic lung compliance measured in anesthetized, tracheotomized, and ventilated mice after exposure to air or ozone. Mice were deeply anesthetized and sedated with medetomidine, 0.5 mg/kg, and tiletamine/zolpidem, 50 mg/kg and ventilated at 7–8 cc/kg with a mouse ventilator for the duration of the procedure. Measurements were made with the mouse in the supine position using a plethysmograph. * Symbol denotes P=0.005 as compared to the corresponding value in the reciprocal chimeric strain.