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. 2006 Sep;70(3):789–829. doi: 10.1128/MMBR.00040-05

TABLE 2.

Nuclear substrates for covalent mono-ADP-ribosylation

Substrate(s) Amino acid modification sites Functional relevance References
Histone H1 (H1.1, H1.2, H1.3, H1.4, H1.5) Glutamic acid residues E2 (all), E15 (all), E114 (H1.2), E115 (H1.3/H1.4), E117 (H1.5); arginine residue R33 (H1.3); phosphoserine residues(?) NAa 293, 308, 335, 373, 389, 416
Histone H2A Glutamic acid residues, arginine residues, phosphoserine residues (?) NA 141, 308, 373, 389
Histone H2B Glutamic acid residue E2, arginine residues, phosphoserine residues (?) NA 55, 292, 308, 373, 389
Histone H3 Arginine residues, phosphoserine p-S57 (?) NA 141, 308, 373, 389
Histone H4 Arginine residues, phosphoserine residues (?) NA 141, 308, 373, 389
High-mobility-group proteins HMGA1a, HMGA1b, HMGA2, MGB1, HMGB2, HMGN1, HMGN2 Arginine and glutamic acid residues (?) NA 117, 148, 394-396, 405
Low-mobility-group proteins (?)
a

NA, not analyzed.