TABLE 3.
Postulated nuclear poly-ADP-ribose-associated proteins in vivo
| Substrate(s) | Proposed functional relevance | Reference(s) |
|---|---|---|
| Histones H1 (H1.1, H1.2, H1.3, H1.4, H1.5), H2A, H2B, H3, H3.1, H4 | Inhibition of DNA binding activity | 129, 213, 322, 324, 367 |
| High-mobility-group proteins HMGA1a, HMGA1b, HMGA2, HMGB1, HMGB2, HMGN1, HMGN2 | NAa | 117, 135, 324, 325 |
| Low-mobility-group protein | NA | 117 |
| Poly-ADP-ribose polymerases PARP-1, PARP-1b, PARP-2, PARP-3, PARP-4, PARP-5, PARP-6a, PARP-6b | Inhibition of DNA binding activity? | 20 |
| Topoisomerase I, topoisomerase II | Inhibition of catalytic activity | 121, 190, 355, 372 |
| A24 protein | NA | 213, 322, 368 |
| Heterogeneous ribonucleoproteins hnRNP A1, hnRNP A2/B1, hnRNP C1/C2, hnRNP G, hnRNP H, hnRNP K, hnRNP M | NA | 129 |
| Lamin A/C | NA | 3, 377 |
| Numatrin/B23 | NA | 226 |
| Nucleolin/C23 | NA | 226 |
| Centromere-binding proteins CENPA, CENPB, Bub3 | NA | 349 |
| MARCKS F52/MacMARCKS/MRP50/GAP-43 | NA | 69, 352 |
| p53 | Inhibition of DNA binding | 249, 321, 372 |
| DNA polymerase alpha | Inhibition of catalytic activity | 114, 364 |
| PCNA | Inhibition | 114, 364 |
| Telomeric repeat binding factor-1 | Inhibition of DNA binding | 376 |
| CTCF | Enhancement of DNA binding | 454 |
| NuMA | NA | 68 |
a
NA, not analyzed.