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. 2006 Sep;70(3):755–788. doi: 10.1128/MMBR.00008-06

TABLE 10.

Staphylococcal proteins with (potential) Sec-type signal peptides and (potential) signals for covalent cell wall binding

Identification no. Protein Function Signal
15925728 SA0022 Hypothetical protein, similar to 5′-nucleotidase LPKTG
15925815 Spa Immunoglobulin G binding protein A precursor LPETG
15925838 SasD Hypothetical protein LPAAG
15926239a SdrC Ser-Asp-rich, fibrinogen-binding bone sialoprotein-binding protein LPETG
15926240b,c SdrD Ser-Asp-rich, fibrinogen-binding bone sialoprotein-binding protein LPETG
15926241a,c SdrE Ser-Asp-rich, fibrinogen-binding bone sialoprotein-binding protein LPETG
15926464 ClfA Fibrinogen-binding protein A, clumping factor LPDTG
15926713 IsdB Conserved hypothetical protein LPKTG
15926714 IsdA Cell surface protein LPKTG
15926715 IsdC Conserved hypothetical protein NPQTN
15927308b HarA Hypothetical protein LPKTG
15927333c,d SasC Hypothetical protein, similar to FmtB protein LPNTG
15927741a,e SasB FmtB protein LPDTG
15928076a,b,f Aap Hypothetical protein, similar to accumulation-associated protein LPKTG
15928081b,c FnbB Fibronectin-binding protein homolog LPETG
15928082c FnbA Fibronectin-binding protein homolog LPETG
15928174g SasK Hypothetical protein LPKTG
15928216 ClfB Clumping factor B LPETG
15928232a SasF Conserved hypothetical protein LPKAG
15928240h SasA Hypothetical protein, similar to streptococcal hemagglutinin protein LPDTG
57652419i Pls Methicillin-resistant surface protein LPDTG
21284341j Cna Collagen adhesin precursor LPKTG
27467746k SE0828 Lipoprotein VsaC LPETG
27468418k SE1500 Hypothetical protein LPKTG
27468419k SE1501 Hypothetical protein LPNTG
27468546k SE1628 Hypothetical protein LPETG
27469070k SE2152 Hypothetical protein LPNTG
a

Also present in S. epidermidis.

b

The genes encoding SdrC, HarA, and FnbB are not present in S. aureus MRSA252.

c

Has a lower SignalP score than our threshold score.

d

Truncated in S. aureus Mu50, thereby missing the C-terminal part containing the LPXTG motif.

e

The gene encoding SasB is not present in S. aureus MRSA252 and MSSA476 and is truncated in S. aureus MW2.

f

Truncated in S. aureus Mu50 and N315, thereby missing the C-terminal part containing the LPXTG motif.

g

The gene encoding SasK is not present in S. aureus COL, MRSA252, and MSSA476 and is truncated in S. aureus MW2, thereby missing the N-terminal signal peptide.

h

Contains an unusually long signal peptide (90 amino acids).

i

The gene encoding Pls is present only in S. aureus COL.

j

The gene encoding Cna is not present in S. aureus COL, Mu50, and N315.

k

Present only in S. epidermidis.