. 2006 Sep;70(3):755–788. doi: 10.1128/MMBR.00008-06

TABLE 3.

Secretion machinery of S. aureus, S. epidermidis, and B. subtilis^a

Pathway and component	Protein(s)	Presence of protein
Pathway and component	Protein(s)	S. aureus	S. epidermidis	B. subtilis
Sec pathway
Chaperone	Ffh	+	+	+
	FtsY	+	+	+
	FlhF	−	−	+
	CsaA	−	−	+
Translocation motor	SecA1	+	+	+
Translocation motor	SecA2	+	+	−
Translocation channel	SecY1	+	+	+
Translocation channel	SecY2	+	+	−
	SecE	+	+	+
	SecG	+	+	+
	SecDF	+	+	+
	YajC (YrbF)	+	+	+
Lipid modification	Lgt	+	+	+
Signal peptidase	SpsA (inactive)	+	+	−
	SpsB (SipSTUV)	+	+^b	+
	SipW (ER-type)	−	−	+
	LspA	+	+^c	+
Folding catalyst	PrsA	+	+	+
	BdbC	−	−	+
	DsbA (BdbD)	+	+	+
Tat pathway
Translocase	TatA	+	−	+
Translocase	TatC	+	−	+
Pseudopilin pathway	ComGA	+	+	+
	ComGB	+	+	+
	ComC	+	+	+
Bacteriocins	Bacteriocin-specific ABC transporters	Unknown	Unknown	+
Holins	CidA (holin)	+	+	+
	LrgA (anitholin)	+	+	+
ESAT-6 pathway	EsaA	+	−	+
	EsaB	+	−	+
	EsaC^d	+	−	−
	EssA	+	−	−
	EssB	+	−	+
	EssC	+	−	+

Based on BLAST searches with the corresponding proteins of B. subtilis in the finished genome database (http://www.ncbi.nlm.nih.gov/sutils/genom_table.cgi).

Two potentially active type I SPases are present in this strain and share homology with B. subtilis SipS and SipU.

Two LspA proteins are present in this strain.

This protein is missing in the S. aureus MRSA252 strain.