TABLE 3.
In vitro susceptibilities of 200 Malassezia sp. isolates to three antifungal agents as determined by the modified urea and CLSI broth microdilution methodsa
| Species (no. of isolates) | Voriconazole
|
Itraconazole
|
Ketoconazole
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| MIC range | MIC50 | MIC90 | MIC range | MIC50 | MIC90 | MIC range | MIC50 | MIC90 | |
| M. furfur (52)b | 0.03-1 | 0.25 | 0.5 | 0.03-0.5 | 0.125 | 0.25 | 0.03-1 | 0.25 | 0.5 |
| M. globosa (74)c | 0.03-≥8 | 2 | ≥8 | 0.015-≥8 | 4 | ≥8 | 0.0015-≥8 | 8 | ≥8 |
| M. obtusa (6)b | 0.03-0.25 | 0.125 | NAd | 0.015-0.25 | 0.06 | NA | 0.125-1 | 0.25 | NA |
| M. pachydermatis (2)b | 0.125-0.25 | NA | NA | 0.03-0.125 | NA | NA | 0.06-0.25 | NA | NA |
| M. restricta (16)c | 0.06-8 | 0.125 | 2.0 | 0.015->8 | 0.125 | 2.0 | 0.015-≥8 | 0.125 | 1.0 |
| M. sympodialis (50)b | 0.015-1 | 0.06 | 0.25 | 0.015-2 | 0.06 | 1.0 | 0.015-4 | 0.125 | 0.5 |
a
Results were obtained for the six species with Christensen's urea supplemented with 0.1% Tween 80 and 0.5% Tween 40, pH 5.2. MICs are in micrograms per milliliter.
b
Results were obtained at 72 h.
c
Results were obtained at 96 h.
d
NA, not applicable.