TABLE 3.

Performances of the laboratories in the identification of precore mutants (position 1896)

Parameter	S-based genotyping	HBe status	Viral load determined by TaqMan (log10 copies/ml)	Results for laboratorya:
				Pb	Bb	Eb	Lb	Gc	Hc	Jc	Kc	Mc	Nc
Sample assignment
s1	C	Anti-HBe	4.35	V	V	V	V	V	V	V	V	V	V
s2	A	HBeAg	6.06	WT	V	WT	WT	WT	WT	WT	WT	WT	NT
s3	A	HBeAg	7.02	WT	V	WT	WT	WT	WT	WT	WT	WT	WT
s4	A	Anti-HBe	2.90	WT	WT	Neg	WT	WT	WT	WT	Neg	Neg	WT
s5	F	Anti-HBe	4.52	V	V	V	V	Ind	V	Neg	V	V	V
s6	F	HBeAg	9.54	WT	V	WT	WT	Ind	WT	WT	WT	WT	NT
s8	D	Anti-HBe	4.68	V	V	NT	V	V	V	V	V	V	V
s9	A	HBeAg	8.51	WT	V	WT	WT	WT	Ind	WT	WT	WT	WT
s10	A	Anti-HBe	4.38	WT	V	WT	WT	Ind	WT	WT	WT	WT	WT
s11	B	HBeAg	9.17	WT	V	WT/V	WT	WT	Ind	WT	WT	WT	WT
s14	E	HBeAg	9.25	WT	V	WT	WT	WT	WT	WT	WT	Neg	NT
s15	C	HBeAg	9.07	WT	V	WT	WT	WT	WT	WT	NT	Neg	NT
No. (%) of correct results					3/12 (25)	9/12 (75)	12/12 (100)	9/12 (75)	10/12 (83)	11/12 (92)	10/12 (83)	9/12 (75)	8/12 (67)
No. of false results					8	1	0	0	0	0	0	0	0
No. of negative or untested samples					0	2	0	0	0	1	2	3	4
No. of indeterminate results					0	0	0	3	2	0	0	0	0

^aV, precore stop codon mutation (G to A at nucleotide 1896); Neg, negative; Ind, indeterminate; NT, not tested.

^bInnoLiPA HBV precore (Innogenetics, Gent, Belgium).

^cIn-house direct sequencing method.