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. 2006 Aug 30;44(10):3616–3622. doi: 10.1128/JCM.01187-06

TABLE 1.

Percent agreement at optimal incubation times of either posaconazole or amphotericin B Etest and YeastOne MICs with reference MICs and susceptibility data obtained by the three methods for 92 zygomycete isolatesa

Species (no. of isolates tested) Agent % Agreement of reference with E/Yb MICs (μg/ml) by:
Etest
M38-A
YeastOne
Range G/MIC90 Range G/MIC90 Range G/MIC90
Absidia corymbifera (11) P 100c/100c 0.12-1.0 0.4/0.25 0.25-1.0 0.56/1.0 0.25-1.0 0.56/0.5
A 100d/100d 0.5-2 1.4/1.0 0.25-1.0 0.84/1.0 0.25-0.5 0.67/0.5
Cunninghamella bertholletiae (11) P 100c/100c 0.25-1.0 0.48/1.0 0.25-1.0 0.61/1.0 0.06-1.0 0.53/1.0
A 100c/100c 2->8 4.72/8 2-8 3.45/8 2-4 2.18/2
Mucor spp. (18) P 83c/100c 0.06->8 2.42/8 0.06-4 0.78/1.0 0.12-8 0.93/1.0
A 83d/100d 0.25->8 3.2/1.0 0.25-4 0.79/1.0 0.25-4 0.96/2
M. circinelloides (3) P 100c/100c 0.5-1.0 ND 1.0-2 ND 0.5-1.0 ND
A 100c/100c 0.25-1.0 ND 0.5-1.0 ND 0.5-1.0 ND
M. ramosissimus (3) P 100c/100c 0.5-1.0 ND 1.0-2 ND 0.5-1.0 ND
A 100c/100c 1.0 ND 0.25-1.0 ND 0.5 ND
Rhizopus arrhizus (36) P 91c/100c 0.25->8 3.9/4 0.25-4 1.4/2 0.25-8 1.68/2
A 91c/96d 0.06-2 0.7/2 0.25-4 1.14/2 0.5-8 1.28/2
R. microsporus var. microsporus (4) P 100c/100c 0.5-2 ND 0.5-1.0 ND 0.25-1.0 ND
A 100c/100c 1.0-4 ND 1.0-2 ND 2 ND
Syncephalastrum spp. (3) P 100c/100c 0.5-1.0 ND 0.12-1.0 ND 0.06-0.5 ND
A 100d/100c 0.12-0.25 ND 0.25-0.5 ND 0.12-0.5 ND
Others (3)e P 100c/100c 0.12 ND 0.12-0.5 ND 0.03-0.25 ND
A 100d/100c 0.25-2 ND 0.25-1.0 ND 0.12-0.25 ND
All zygomycetes (92) P 95.7c/100c 0.06->8 2.29/8 0.06-4 0.91/2 0.03-8 1.05/2
A 96.5/99.3 0.06->8 2.2/4 0.25-8 1.26/2 0.12-8 1.2/2
a

NCCLS M38-A broth microdilution method; G, geometric mean MIC; MIC90, MICs for 90% of the isolates tested.

b

Percentage of agreement between MICs by reference and Etest (E) and between reference and YeastOne (Y); P, posaconazole; A, amphotericin B.

c

Highest percentage of agreement was obtained at 16 to 24 h (commercial methods) and 24 h (reference method).

d

Highest percentage of agreement was obtained at 48 h (commercial method).

e

Includes 1 Actinomucor elegans and 2 Rhizomucor pusillus isolates.