TABLE 2.

Significantly regulated apoptosis-related genes at 4 h postinfection^a

Gene	Fold change	P value	Description
Apoptosis regulators
Irak2	2.07	0.0381	Mus musculus adult male olfactory brain cDNA, B cell
Bcl10	2.67	0.0394	Leukemia/lymphoma 10
AW260063	3.82	0.0389	Mus musculus transcribed sequences
Bcl2	0.30	0.0231	B-cell leukemia/lymphoma 2
Bat3	0.42	0.0426	HLA-B-associated transcript 3
Bak1	0.42	0.0424	BCL2 antagonist/killer 1
Timm50	0.50	0.027	Translocase of inner mitochondrial membrane 50 homolog (yeast)
Hip1	0.53	0.0284	Huntingtin interacting protein 1
Bad	0.55	0.0301	Bcl-associated death promoter
Bcl2l2	0.56	0.0427	Bcl2-like 2
Taf10	0.58	0.0476	TAF10 RNA polymerase II, TATA box binding protein-associated factor
Bag1	0.60	0.00533	Bcl2-associated athanogene 1
Bcl2l	0.65	0.0416	Bcl2-like
Pmaip1	0.67	0.0479	Phorbol-12-myristate-13-acetate-induced protein 1
Casp2	0.67	0.0279	Caspase 2
Apoptosis inhibitors
Mkl1	0.59	0.0285	RIKEN cDNA 1810012I01 gene
Birc1b	0.70	0.0474	Baculoviral IAP repeat-containing 1b
Apoptosis related
TNF	9.90	0.0392	Tumor necrosis factor alpha
Tnfrsf5	2.88	0.0267	Tumor necrosis factor receptor superfamily, member 5
Myc	3.84	0.0271	Myelocytomatosis oncogene
Tnfrsf6	6.79	0.0267	Tumor necrosis factor receptor superfamily, member 6
Ddit3	0.18	0.0267	DNA damage-inducible transcript 3
Ifld2	0.21	0.042	Induced in fatty liver dystrophy 2
Ifld2	0.29	0.0352	Induced in fatty liver dystrophy 2
Sivab	0.29	0.0394	Cd27 binding protein
Siva	0.40	0.0408	Cd27 binding protein
Ngfrap1	0.53	0.031	Nerve growth factor receptor (TNFRSF16)-associated protein 1
Casp8ap2	0.53	0.0309	Caspase 8-associated protein 2
Trp53inp1	0.55	0.0433	Transformation-related protein 53-inducible nuclear protein 1
Tia1	0.58	0.031	Cytotoxic granule-associated RNA binding protein 1
Gsk3b	0.60	0.0394	Glycogen synthase kinase 3 beta
Pdcd8	0.62	0.0283	Programmed cell death 8
Bbc3	0.62	0.0231	Bcl-2 binding component 3
Elmo2	0.65	0.0271	Engulfment and cell motility 2, ced-12 homolog (Caenorhabditis elegans)
Cfdp	0.68	0.0469	Craniofacial development protein 1
Pdcd5	0.74	0.0393	Programmed cell death 5

^aThe Ifld2 and Siva genes contain two probe sets each. The 36 probe sets (34 genes) are grouped into apoptosis regulators, apoptosis inhibitors, and apoptosis-related genes according to GO assignment. Both pro- and antiapoptosis effects are found. Supplemental Table 3 at http://sitemaker.umich.edu/helab contains signal data and gene information for all the 36 probe sets at different times. No apoptosis is explained in the text.

^bSiva is the Hindu God of destruction.