TABLE 3.
Full restoration of chronic infectivity once constitutive ospC expression is abolisheda
| Transformant | Missing plasmids | No. of positive cultures/total no. of specimens examined
|
|||
|---|---|---|---|---|---|
| Heart | Joint | Skin | All sites | ||
| 5A13/pGE22/03 | cp9, lp25, lp56, lp21, lp5 | 5/5 | 5/5 | 5/5 | 15/15 |
| 5A13/pGE22/07 | cp9, lp25, lp28-4, lp56, lp21, lp5 | 5/5 | 5/5 | 5/5 | 15/15 |
| 5A13/pGE22/16 | cp9, lp25, lp56, lp21, lp5, cp32-3 | 5/5 | 5/5 | 5/5 | 15/15 |
a
Groups of five BALB/c mice were inoculated with transformant 5A13/pGE22/03, 5A13/pGE22/07, or 5A13/pGE22/16 and sacrificed at 5 months postinoculation. Heart, tibiotarsal joint, and skin specimens were harvested and cultured for spirochetes in BSK-H complete medium.