TABLE 3.
Summary of virulence parameters for temporarily neutropenic mice challenged intravenously with three fungal species and their ace2 or swi5 null mutants
| Fungal strain | Challenge dose (CFU/g body wt) | No. of animals tested | Mean survival time (days) ± SD | Mean burden (log CFU/g) ± SD
|
||
|---|---|---|---|---|---|---|
| Kidneys | Brain | Lungs | ||||
| C. albicans CAI-4 + CIp10 | 1.5 × 104 | 12 | 2.1 ± 0.7 | 6.7 ± 0.3 | 4.9 ± 0.6 | 4.7 ± 0.7 |
| C. albicans MK106 (ace2 null) | 1.6 × 104 | 12 | 6.0 ± 7.0 | 6.0 ± 1.0 | 4.5 ± 0.7 | 3.7 ± 0.8 |
| C. glabrata HLS121 (control) | 1.2 × 106 | 12 | 27.9 ± 0.3 | 3.4 ± 1.1 | 2.0 ± 0.5 | 2.5 ± 0.5 |
| C. glabrata HS122 (ace2 null) | 1.6 × 105 | 12 | 3.0 ± 0.6 | 4.8 ± 0.4 | 5.9 ± 0.3 | 6.0 ± 0.4 |
| C. glabrata CK1-1 (swi5 null) | 1.3 × 105 | 12 | 28.0 ± 0.0 | 4.0 ± 0.7 | 3.7 ± 0.3 | 4.0 ± 0.7 |
| S. cerevisiae YJM145 (parent) | 4.2 × 105 | 6 | 9.7 ± 9.5 | 5.5 ± 1.9 | 4.8 ± 1.7 | 5.3 ± 1.0 |
| S. cerevisiae BMEY-5 (ace2 null) | 4.2 × 105 | 6 | 23.8 ± 10.2 | 5.0 ± 1.8 | 3.2 ± 0.8 | 5.9 ± 1.1 |
| S. cerevisiae YCK2 (swi5 null) | 4.2 × 105 | 6 | 23.8 ± 10.2 | 3.4 ± 1.2 | 3.5 ± 0.7 | 5.5 ± 0.3 |