FIG. 3.

(A) Confocal microscopy image of an aggregate of host immune cells 6 days after live infection of PBMC prestimulated with B3501. In addition to intracellular C. neoformans, two enlarged extracellular cryptococcal cells are seen completely surrounded by mononuclear phagocytes and lymphoid host cells. (B) Transmission electron microscope image of a enlarged, extracellular cryptococcal cell surrounded by host cells, protrusions of which are seen to be in close association with the fungal capsule.