FIG. 6.

Effect of addition of IL-6 on control of cryptococcal growth by PBMC prestimulated with encapsulated C. neoformans. PBMC were prestimulated with either heat-killed encapsulated B3501 or heat-killed acapsular CAP67 mutant organisms, with or without the addition of IL-6, for 12 days before addition of live encapsulated organisms. Cryptococcal growth was determined 6 days after live infection. Results are means ± SE from five independent experiments. Growth in wells with PBMC prestimulated with encapsulated B3501 with addition of IL-6 was 0% ± 39% versus 154% ± 72% with no added IL-6 (P = 0.06).