TABLE 5.
Virulence assessments of B. pseudomallei mutants in the hamster model of acute melioidosis
| Strain | Description/gene for mutation | LD50 (CFU) |
|---|---|---|
| DD503 | Parent strain | <10 |
| ATL0378 | ΔBPSL0378 (MarR family regulatory protein) | <10 |
| ATL1876 | ΔBPSL1876 (putative phospholipase) | <10 |
| ATL2025 | ΔBPSL2025 (putative two-component regulatory system) | 1.4 × 104 |
| ATL2515 | ΔBPSL2515 (rpsA; 30S ribosomal protein S1) | <10 |
| ATL3050 | ΔBPSL3050 (trpE; anthranilate synthase component 1) | <10 |
| ATL3320 | ΔBPSL3320 (fliD, flagellar hook-associated protein) | <10 |
| ATS0067 | ΔBPSS0067 (putative phospholipase C precursor) | 4.5 × 104 |
| ATS0464 | ΔBPSS0464 (potI, putrescine transport system permease protein) | <10 |
| ATS1388 | ΔBPSS1388 (putative membrane protein) | <10 |
| ATS1489 | ΔBPSS1489 (putative exported protein) | <10 |
| ATS1530 | ΔBPSS1530 (bprA, putative H-NS-like regulatory protein) | <10 |
| ATCPL2052 | Complemented mutant of ATL2052 | <10 |
| ATCPS0067 | Complemented mutant of ATS0067 | <10 |