Table 1.
Ten PA proteins that represent attractive targets for structure determination
| PA ID | PA no. of amino acids | Z | P(N) | GenPept no. | OMIM no. | OMIM no. of amino acids | Match no. of amino acids | Function of closest NR/OMIM homolog | NRDB |
|---|---|---|---|---|---|---|---|---|---|
| GPA2549 | 80 | 1.1 | 0.99 | 806564 | 603541 | 80 | 60 (54%) | Small nuclear ribonucleoprotein | 5 |
| GPA2288 | 72 | 1.1 | 0.99 | 1708624 | 125855 | 735 | 30 (73%) | Diacylglycerol kinase, α | 0 |
| GPA2261 | 64 | 1.1 | 0.99 | Hypothetical family | 6 | ||||
| GPA2241 | 155 | 1.1 | 0.99 | Hypothetical family | 8 | ||||
| GPA1339 | 115 | 1.2 | 0.91 | 106985 | 170261 | 703 | 78 (67%) | TAP2 transporter, MHC | 215 |
| GPA2230 | 74 | 1.2 | 0.91 | 34525 | 171050 | 431 | 65 (66%) | Multidrug-resistance protein 1 | 1 |
| GPA2464 | 67 | 1.2 | 0.91 | 539960 | 145505 | 546 | 41 (54%) | Hypertension-associated SA | 15 |
| GPA542 | 135 | 1.2 | 0.91 | 3913830 | 172468 | 172 | 105 (48%) | AMP cyclohydrolase | 36 |
| GPA2413 | 75 | 1.2 | 0.91 | 2342473 | 160776 | 346 | 49 (57%) | Nonmuscle myosin | 0 |
| GPA2606 | 73 | 1.2 | 0.91 | Hypothetical family | 17 |
Each protein has a high probability of being a novel fold [P(N) > 90%]. Also, these proteins either are homologs of human disease-related proteins (OMIM database) or are members of large families of proteins of unknown function.