TABLE 2.
Effects of inhibitors of signaling pathways on 3O12C-HSL-induced chemotaxis
| Inhibitor | Target protein | IC50a |
|---|---|---|
| Gefinitib | Tyrosine kinase | 0.1 μM |
| Pertussis toxin | G protein | NI |
| U73122 | Phospholipase C | 1 μM |
| Staurosporin | Protein kinase C | 0.125 nM |
| SB203580 | Mitogen-activated protein kinase | 0.1 μM |
| PD98059 | Extracellular protein kinase | NI |
| Wortmannin | Phosphoinositol-3-kinase | NI |
a
IC50, concentration that inhibited chemotaxis by 50%. The values are means of three independent experiments performed using cells from different donors. NI, no inhibition.