TABLE 2.
Inhibitor | Target protein | IC50a |
---|---|---|
Gefinitib | Tyrosine kinase | 0.1 μM |
Pertussis toxin | G protein | NI |
U73122 | Phospholipase C | 1 μM |
Staurosporin | Protein kinase C | 0.125 nM |
SB203580 | Mitogen-activated protein kinase | 0.1 μM |
PD98059 | Extracellular protein kinase | NI |
Wortmannin | Phosphoinositol-3-kinase | NI |
IC50, concentration that inhibited chemotaxis by 50%. The values are means of three independent experiments performed using cells from different donors. NI, no inhibition.