TABLE 2.
Immunization of mice with the native Dam-overproducing strain of A. hydrophila provides protection against subsequent challenge with the lethal dose of WT A. hydrophila SSU
| Period of immunization with the native Dam overproducera (no. of wks) | No. of survivals/total no. of animals infected
|
||
|---|---|---|---|
| Over the period of immunization | After immunization and challenge with two LD50s of WT A. hydrophilab | For control animals given DPBS and then challenged with two LD50s of WT A. hydrophilab | |
| 1 | 10/10 | 10/10 | 0/10 |
| 3 | 10/10 | 10/10 | 0/10 |
| 5 | 10/10 | 10/10 | 0/10 |
| 6 | 10/10 | 10/10 | 0/10 |
a
Animals were immunized with 1 × 107 CFU of the Dam-overproducing strain.
b
Animals were challenged with 1 × 107 CFU of WT A. hydrophila, which represented approximately two LD50s.