TABLE 5.

L. interrogans genes of known or predicted function which were down-regulated at physiological temperatures compared with environmental temperatures in three sets of biological replicates

Function and ORFa	Mean fold down-regulation	Gene	COG categoryb	Description of gene product
Information storage and processing
LA0787	−1.6		J	rRNA methylase
LA2101	−1.5		K	RNA polymerase sigma subunit
LA0281	−1.9	alkA	L	DNA-3-methyladenine glycosylase II
LA2347	−1.7	xerC	L	Tyrosine site-specific recombinase XerC
LA4049	−3.7	srmB	L	ATP-dependent RNA helicase (superfamily II)
Cellular processes and signaling
LA3011	−2.1		D	Cell division protein with ATPase domain
LA0791	−1.5		M	Transglycosylase
LA2058	−1.6	ddlA	M	d-alanine-d-alanine ligase
LA2200	−2		M	Amidase
LA3615	−1.5		M	OmpA family protein
LA4078	−1.5	lnt	M	Apolipoprotein N-acyltransferase
LB323	−1.7		M	Transglycosylase
LA2666	−1.7	flgA	N	Endoflagellar basal body P-ring biosynthesis protein
LA3778	−1.6	ligB	N	LigB lipoprotein
LA4309	−1.6	flgK	N	Endoflagellar hook junction protein
LA0036	−1.5		O	HSP33 family chaperone
LA2278	−1.5		O	DnaJ-related molecular chaperone
LA2949	−1.8		O	Trypsin-like serine protease
LA0049	−1.8		T	Methyl-accepting chemotaxis protein
LA0565	−1.5		T	Adenylate cyclase
LA1681	−1.5		T	Phosphate starvation-inducible protein
LA1919	−1.6		T	DNA-binding transcriptional activator, SARP family
LA2246	−1.5		T	Methyl-accepting chemotaxis protein
LB139	−1.7		T	Regulator of sigma subunit
LA2014	−1.6		V	CreD-like protein
LA3871	−1.6		V	Cation/multidrug efflux pump
LA4287	−1.6		V	ATP-binding protein of an ABC transporter complex
Metabolism
LB165	−3.3		C	Ferredoxin related-protein
LA0693	−1.6	lysC	E	Aspartate kinase
LA4200	−1.7		E	Amine oxidase (flavin containing)
LB123	−1.6	aroK	E	Shikimate kinase
LA0786	−1.6		G	Glycosyltransferase
LA0970	−1.7		G	Permease component of an ABC transporter complex
LA1392	−1.6		G	Sugar kinase
LB152	−1.6	cobU	H	Adenosylcobinamide kinase, adenosylcobinamide-phosphate guanylyltransferase
LB157	−1.8	cobJ	H	Precorrin-3B C(17)-methyltransferase
LB159	−1.6	cobF	H	Precorrin-6A synthase (deacetylating)
LB160	−1.6	cobL	H	Precorrin-6Y C5,15-methyltransferase (decarboxylating)
LB161	−2.2	cobH	H	Precorrin-8X methylmutase or isomerase
LA0438	−1.7		I	Acyl-CoA dehydrogenase
LA4245	−1.8		P	Monooxygenase
LA4246	−1.9	phoD	P	Phosphodiesterase I

^aForty-eight ORFs coding for hypothetical proteins (those grouped into COG R, S, or − or which are conserved or unique hypothetical proteins) were omitted from this table. For a complete listing, see Table S2 in the supplemental material.

^bCOG categories are as described for Fig. 3.