TABLE 2.

Significantly overexpressed GO terms derived from differentially expressed genes upregulated in presymptomatic experimental and naturally acquired malaria^a

Data set, GO term, and description	No. of genes	P value
Group 1 only
GO:0006955, immune response	22	3.03E−05
GO:0006954, inflammatory response	17	4.84E−07
GO:0016567, protein ubiquitination	12	1.54E−02
GO:0007267, cell-cell signaling	12	3.92E−02
GO:0000074, regulation of cell cycle	10	4.83E−02
GO:0042981, regulation of apoptosis	7	3.81E−03
Group 2 only
GO:0006355, regulation of transcription	324	5.49E−03
GO:0005739, mitochondrion	202	6.13E−09
GO:0006412, protein biosynthesis	104	2.56E−09
GO:0006915, apoptosis	79	5.03E−03
GO:0000398, nuclear mRNA splicing	73	3.57E−07
GO:0006886, intracellular protein transport	71	1.60E−04
Groups 1 and 2 (shared)
GO:0006955, immune response	108	<1E−10
GO:0006118, electron transport	52	2.21E−04
GO:0006915, apoptosis	48	4.19E−04
GO:0006512, ubiquitin cycle	44	1.62E−04
GO:0006886, intracellular protein transport	43	5.29E−05
GO:0006457, protein folding	41	6.41E−05

^aThe table shows six representative statistically significant (corrected P value) GO terms derived from Onto Express for each analysis. A full list of GO terms are available in Table S2 in the supplemental material.