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Mitochondrial dNTP levels in wild-type and mutant MEFs and human lymphoblasts. For the MEFs, mitochondria were isolated from a wild-type (blue bars) or mutant (red bars) culture on two occasions. dNTP levels were measured in duplicate and averaged (±SD). Lymphoblast nucleotide levels were determined from mitochondria isolated from two control (yellow bars) or patient (green bars) cultures and averaged (±SD) according to affection status.
