Table 1.

Levels of ThPP and ThMP

Cell type	Mitochondria		Postmitochondrial supernatant
	ThPP*	ThMP*	ThPP*	ThMP*
Wild-type MEFs	2.02 ± 0.25	0.19 ± 0.02	2.75 ± 0.91	0.28 ± 0.04
Mutant MEFs	Not detectable	Not detectable	6.88 ± 0.42†	1.05 ± 0.05†
Control lymphoblasts	1.03 ± 0.25	0.37 ± 0.01	3.23 ± 0.26	0.22 ± 0.01
Patient lymphoblasts	0.10 ± 0.01†	0.02 ± 0.01†	4.63 ± 0.21†	0.39 ± 0.12†

Data represent the mean ± SEM of three independent experiments.

*Data are presented as ng/mg of total cellular protein.

^†Values are significantly different from control (P < 0.05).