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Development of serum anti-NanA IgG antibodies during the first 24 months of life in pnc− and pnc+ children. Numbers in parentheses indicate the numbers of samples analyzed at each age point. During the follow-up, the proportion of pnc+ children increased, while the proportion of pnc− children decreased. Geometric mean concentrations with 95% confidence intervals are given. *, P < 0.001 for pnc+ versus pnc− children (Student's t test).
