Figure 5.

Calculated relationship of the value of k_on (e.g., the second order rate constant for reaction with sulfite) as a function of the value of k₅ for the model described in the text. The values of k_on were calculated from the ratio k₁k₃k₅/(k₂k₄ + k₂k₅ + k₃k₅) as described in the text. The same values were confirmed by computer simulation of the three-step binding model. The two sets of curves simulate a 5-fold viscosity effect on the entry and positioning of reactant before the observed chemical step, k₅.