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Two types of interactions, ICIs and NICIs. (A). ICIs: binary interactions within complexes (solid line). (B) NICIs: binary interactions not within complexes (dashed line). I, NICI between two complexes. II, NICI between a complex and a free protein. III, NICI between two free proteins. The counts of the various types of interacting pairs based on reliable data sets are shown in parentheses (for generation of data sets, see Fig. 2 and Materials and Methods).
